ABSTRACT
A inserção da Odontologia no Sistema Único de Saúde, como estratégia de transformação da prática, introduziu novas formas de organização na busca pela melhoria das condições de saúde bucal da população. O objetivo do trabalho foi identificar práticas adotadas pela Equipe de Saúde Bucal na prevenção e promoção da saúde bucal das co- munidades assistidas pela Estratégia Saúde da Família. Trata-se de uma revisão de litera- tura, com uma busca sistematizada nas bases de dados Biblioteca Virtual em Saúde e Scielo, utilizando os descritores: programa saúde da família, estratégia saúde da família, saúde bucal e odontologia. Os critérios de inclusão foram: estudos qualitativos, surveys e mistos, que abordem práticas adotadas pela Equipe de Saúde Bucal da Estratégia Saúde da Família, na prevenção e promoção da saúde bucal. A busca resultou em 435 estudos, após remoção das duplicatas, leitura de títulos, resumos e verificação dos critérios de inclusão foram incluídos 18 artigos. As práticas identificadas foram: educação em saúde, visita domiciliar, humanização do cuidado, educação permanente em saúde e intersetori- alidade. Os resultados mostraram que as práticas de prevenção e promoção de saúde ado- tadas pela Equipe de Saúde Bucal da Estratégia Saúde da Família foram viáveis, uma vez que emergiram de estratégias difundidas pelas políticas públicas, evidenciando a indisso- ciabilidade entre saúde bucal e saúde geral dos usuários e comunidades, contribuindo no processo de consolidação do Sistema Único de Saúde.
The inclusion of Dentistry in the Unified Health System, as a practice transformation strategy, introduced new forms of organization in the quest to improve the oral health conditions of the population. The objective of this work was to identify prac- tices adopted by the Oral Health Team in the prevention and promotion of oral health in communities assisted by the Family Health Strategy. This is a literature review, with a systematic search, in the Virtual Health Library and Scielo databases, using the descrip- tors: family health program, family health strategy, oral health and dentistry. The inclu- sion criteria were: qualitative studies, surveys and mixed, which address practices adop- ted by the Oral Health Team of the Family Health Strategy, in the prevention and promo- tion of oral health. The search resulted in 435 studies, after removing duplicates, reading titles, abstracts and checking the inclusion criteria, 18 articles were included. The identi- fied practices were: health education, home visits, humanization of care, permanent health education and intersectoriality. The results showed that the prevention and health promo- tion practices adopted by the Oral Health Team of the Family Health Strategy were viable, since they emerged from strategies disseminated by public policies, evidencing the inse- parability between oral health and the general health of users and communities , contri- buting to the consolidation process of the Unified Health System.
La inclusión de la Odontología en el Sistema Único de Salud, como estra- tegia de transformación de la práctica, introdujo nuevas formas de organización en la búsqueda de mejorar las condiciones de salud bucal de la población. El objetivo de este trabajo fue identificar las prácticas adoptadas por el Equipo de Salud Bucal en la preven- ción y promoción de la salud bucal en las comunidades asistidas por la Estrategia Salud de la Familia. Se trata de una revisión bibliográfica, con búsqueda sistemática, en la Bi- blioteca Virtual en Salud y en las bases de datos Scielo, utilizando los descriptores: pro- grama de salud familiar, estrategia de salud familiar, salud bucal y odontología. Los cri- terios de inclusión fueron: estudios cualitativos, encuestas y mixtos, que aborden las prác- ticas adoptadas por el Equipo de Salud Bucal de la Estrategia Salud de la Familia, en la prevención y promoción de la salud bucal. La búsqueda resultó en 435 estudios, luego de eliminar duplicados, leer títulos, resúmenes y verificar los criterios de inclusión, se inclu- yeron 18 artículos. Las prácticas identificadas fueron: educación en salud, visitas domi- ciliarias, humanización del cuidado, educación permanente en salud e intersectorialidad. Los resultados mostraron que las prácticas de prevención y promoción de la salud adop- tadas por el Equipo de Salud Bucal de la Estrategia Salud de la Familia fueron viables, ya que surgieron de estrategias difundidas por las políticas públicas, evidenciando la in- separabilidad entre la salud bucal y la salud general de los usuarios y comunidades, con- tribuyendo al proceso de consolidación del Sistema Único de Salud.
Subject(s)
Patient Care Team , Oral Health , Dentistry , Public Policy , Health Education , Intersectoral Collaboration , Libraries, Digital , Humanization of AssistanceABSTRACT
O objetivo deste estudo é analisar a cobertura do número de equipes de Saúde da Família (eSF) e Saúde Bucal (eSB) nas Macrorregiões de Saúde (MS) do Paraná, entre 2007 e 2022. Trata-se de um estudo ecológico longitudinal, utilizando dados secundários do Datasus: eSF, eSF com Saúde Bucal modalidade I (ESFSB MI) e eSF com Saúde Bucal modalidade II (ESFSB MII). Foram realizadas análises descritivas e correlação de Pearson. A MS leste apresentou o maior número de eSF e ESFSB MI e MII. Ao correlacionar as variáveis número de eSF com ESFSB MI e ESFSB MII, as MS norte e noroeste apresentaram correlação positiva muito forte e positiva forte (r=0,91 e r=0,85), respectivamente. Assim, evidenciou-se relação direta e proporcional entre o número de eSB vinculadas à Estratégia Saúde da Família nas MS do Paraná, para auxiliar gestores, trabalhadores e pesquisadores no planejamento e avaliação de políticas públicas direcionadas à saúde bucal no Sistema Único de Saúde.
This study aimed to analyze the coverage of the number of Family Health (eSF) and Oral Health (eSB) teams in the Health Macroregions (MS) in the state of Paraná, between 2007 and 2022. This was a longitudinal ecological study, using secondary data from Datasus: eSF, eSF with Oral Health in Modality I (ESFSB MI), and eSF with Oral Health in Modality II (ESFSB MII). Descriptive analyses and Pearson's correlation were applied. MS East had the highest number of eSF and ESFSB MI and MII. When correlating the number of eSF with ESFSB MI and ESFSB MII, the North and Northwest MS showed a very strong positive and strong positive correlation (r=0.91 and r=0.85), respectively. Thus, a direct and proportional relationship was found between the number of eSB linked to the Family Health Strategy in the MS in the state of Paraná, helping managers, workers, and researchers in planning and evaluation of public policies aimed at oral health in the Brazilian Unified Health System.
ABSTRACT
(-)-α-Bisabolol (BISA) is an unsaturated monocyclic sesquiterpenes compound, mainly found in the essential oil of chamomile (Matricaria chamomilla). It has been reported that this compound has several biological activities, but there are few studies evaluating the activity of this compound in the systemic inflammatory response in infectious processes. The aim of this study was to evaluate the effect of BISA on the inflammatory response and survival rate in a systemic infection model, and in vitro neutrophils phagocytic activity. BISA at concentration of 3, 10, 30, and 90 µg/ml did not presented in vitro cytotoxicity in MTT assay, and at concentrations of 1 and 3 µg/ml the BISA treatment increased in vitro phagocytic neutrophil activity. For the inflammatory response study, we verified the BISA treatment effect in a cecal ligation and puncture (CLP)-induced systemic infection model in mice; in this model, we demonstrate that BISA at dose of 100 mg/kg reduced the leukocyte recruitment in peritoneal cavity; at dose of 200 mg/kg, the NO concentration was increased in the peritoneal cavity. The bacteria CFU number was reduced in mice blood in the BISA treatment, at doses of 100 and 200 mg/kg. The BISA treatment at doses of 50 and 100 mg/kg increased the myeloperoxidase activity and reduction NO production in lung tissue of mice in CLP model. At dose of 100 mg/kg, the BISA treatment was able to reduce the mortality rate of mice submitted to CLP-induced sepsis and observed for 7 days. The results suggest an effect of BISA on inflammatory response, with activity on leukocyte chemotactic and NO production, in addition to increasing the survival rate of animals submitted to CLP model.
Subject(s)
Anti-Inflammatory Agents/pharmacology , Inflammation/prevention & control , Monocyclic Sesquiterpenes/pharmacology , Neutrophils/drug effects , Phagocytosis/drug effects , Sepsis/drug therapy , Animals , Bacterial Load , Cells, Cultured , Chemotaxis, Leukocyte/drug effects , Disease Models, Animal , Female , Host-Pathogen Interactions , Inflammation/immunology , Inflammation/metabolism , Inflammation/microbiology , Lung/drug effects , Lung/immunology , Lung/metabolism , Lung/microbiology , Mice, Inbred C57BL , Neutrophils/immunology , Neutrophils/metabolism , Neutrophils/microbiology , Nitric Oxide/metabolism , Peritoneum/drug effects , Peritoneum/immunology , Peritoneum/metabolism , Peritoneum/microbiology , Sepsis/immunology , Sepsis/metabolism , Sepsis/microbiologyABSTRACT
Lavandula angustifolia is a plant of Lamiaceae family, with many therapeutic properties and biological activities, such as anticonvulsant, anxiolytic, antioxidant, anti-inflammatory, and antimicrobial activities. The aim of this study was to evaluate the effect of Lavandula angustifolia Mill. essential oil (LEO) on acute inflammatory response. LEO was analyzed using gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy (NMR) methods and showed predominance of 1,8-cineole (39.83%), borneol (22.63%), and camphor (22.12%). LEO at concentrations of 0.5, 1, 3, and 10 µg/ml did not present in vitro cytotoxicity. Additionally, LEO did not stimulate the leukocyte chemotaxis in vitro. The LEO topical application at concentrations of 0.25, 0.5, and 1 mg/ear reduced edema formation, myeloperoxidase (MPO) activity, and nitric oxide (NO) production in croton oil-induced ear edema model. In carrageenan-induced paw edema model, LEO treatment at doses of 75, 100, and 250 mg/kg reduced edema formation, MPO activity, and NO production. In dextran-induced paw edema model, LEO at doses of 75 and 100 mg/kg reduced paw edema and MPO activity. In conclusion, LEO presented anti-inflammatory activity, and the mechanism proposed of LEO seems to be, at least in part, involving the participation of prostanoids, NO, proinflammatory cytokines, and histamine.
ABSTRACT
High doses of acetaminophen (APAP) lead to acute liver damage. In this study, we evaluated the effects of citral in a murine model of hepatotoxicity induced by APAP. The liver function markers alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (γGT) were determined to evaluate the hepatoprotective effects of citral. The livers were used to determine myeloperoxidase (MPO) activity and nitric oxide (NO) production and in histological analysis. The effect of citral on leukocyte migration and antioxidant activity was evaluated in vitro. Citral pretreatment decreased significantly the levels of ALT, AST, ALP, and γGT, MPO activity, and NO production. The histopathological analysis showed an improvement of hepatic lesions in mice after citral pretreatment. Citral inhibited neutrophil migration and exhibited antioxidant activity. Our results suggest that citral protects the liver against liver toxicity induced by APAP.
ABSTRACT
To investigate the hepatoprotective effect of Cymbopogon citratus or lemongrass essential oil (LGO), it was used in an animal model of acute liver injury induced by acetaminophen (APAP). Swiss mice were pretreated with LGO (125, 250 and 500[Formula: see text]mg/kg) and SLM (standard drug, 200[Formula: see text]mg/kg) for a duration of seven days, followed by the induction of hepatotoxicity of APAP (single dose, 250[Formula: see text]mg/kg). The liver function markers alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma-glutamyl transferase were determined to evaluate the hepatoprotective effects of the LGO. The livers were used to determine myeloperoxidase (MPO) activity, nitric oxide (NO) production and histological analysis. The effect of LGO on leukocyte migration was evaluated in vitro. Anti-oxidant activity was performed by assessing the free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) in vitro. LGO pretreatment decreased significantly the levels of ALT, AST and ALP compared with APAP group. MPO activity and NO production were decreased. The histopathological analysis showed an improved of hepatic lesions in mice after LGO pretreatment. LGO inhibited neutrophil migration and exhibited anti-oxidant activity. Our results suggest that LGO has protective activity against liver toxicity induced by paracetamol.
Subject(s)
Acetaminophen/adverse effects , Analgesics, Non-Narcotic/adverse effects , Antipyretics/adverse effects , Chemical and Drug Induced Liver Injury/etiology , Chemical and Drug Induced Liver Injury/prevention & control , Cymbopogon/chemistry , Oils, Volatile/therapeutic use , Phytotherapy , Animals , Chemical and Drug Induced Liver Injury/drug therapy , Disease Models, Animal , Male , Mice , Oils, Volatile/administration & dosage , Oils, Volatile/isolation & purification , Oils, Volatile/pharmacologyABSTRACT
PURPOSE: The aim of this study was to evaluate the effect of Pogostemon cablin essential oil (PEO) on leukocyte behavior in the inflammatory response. METHODS AND RESULTS: PEO was analyzed using Gas Chromatography/Mass Spectrometry (GC/SM) and Nuclear Magnetic Resonance Spectroscopy (NMR) methods and showed predominance of patchoulol (38.50%), α-bulnesene (20.37%), α-guaiene (12.31%), seychellene (8.33%) and α-patchoulene (4.91%). PEO at concentrations of 1, 3, 10, 30, 60 and 90µg/ml reduced the in vitro neutrophil chemotaxis toward fMLP, and at concentrations of 3 and 10µg/ml, increased the phagocytic activity of neutrophils. Topical application of PEO in high concentrations promoted an increase of ear edema and myeloperoxidase (MPO) activity. However, the oral treatment with 100, 200 and 300mg/kg reduced leukocyte recruitment, nitric oxide (NO) production, and rolling and adherent leukocyte number in the microcirculation. CONCLUSION: PEO affects the leukocyte behavior, and the mechanism proposed of PEO seems to be, at least in part, involving the participation of NO and pro-inflammatory cytokines.
